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Ansari, N. A.
- An Experimental Study of Drug Interactions of Diclofenac with Commonly Used Drugs for Diabetes Mellitus in Rabbits
Authors
1 Maharishi Markendeshwer Institute of Medical Sciences & Research Mullana, Haryana, IN
2 Department of Pharmacology, Ganesh Shankar Vidyarthi Memorial Medical College Kanpur, Uttar Pradesh, IN
Source
International Journal of Medical and Dental Sciences, Vol 2, No 2 (2013), Pagination: 195-200Abstract
Insulin, Glibenclamide and Tolbutamide are some of the frequently used drugs for the most common metabolic disorders, diabetes mellitus. Along with hypoglycaemic drugs diabetic patient is exposed to variety of drugs. NSAIDs are one of the commonly used drugs in this metabolic syndrome. When a patient on hypoglycaemic drugs receives NSAIDs there are chances of drug interactions. This study was undertaken in the department of Pharmacology, GSVM medical college, Kanpur (UP) after approval by the institutional animal ethics committee to find out the interaction if any between Diclofenac and three hypoglycaemic drugs i.e. insulin, glibenclamide and tolbutamide.Young healthy rabbits were divided into six groups: five rabbits in each group. First group received Insulin 1 u/kg subcutaneously; second Glibenclamide 0.05 mg/kg orally; third Tolbutamide 40 mg/kg orally; fourth Diclofenac 1mg/kg orally and insulin 1mg/kg s.c. simultaneously; fifth glibenclamide 0.05mg/kg orally at 0 hour and diclofenac 1mg/kg orally at 2 hours and sixth tolbutamide 40mg/kg orally at 0 hour and diclofenac 1mg/kg orally at 2 hours. Blood samples were taken at 0, 1, 2, 4 and 6 hours for blood sugar estimation. Mean blood sugar levels reduced significantly from their fasting levels when insulin, glibenclamide and tolbutamide were administered. However blood sugar levels did not showed any significant changes when diclofenac was administered along with insulin, glibenclamide and tolbutamide in comparison to when insulin, glibenclamide and tolbutamide were given alone. The results showed that diclofenac does not interact with insulin, glibenclamide and tolbutamide on blood sugar levels in rabbits.No Abstract.
Keywords
Diclofenac, Diabetes Mellitus, Glibenclamide, Insulin, Tolbutamide.- Generation Mean Analysis of Quantitative Traits in Restorer Lines of Rice (Oryza sativa L.)
Authors
1 Department of Seed Science and Technology, College of Agriculture, Prof. Jayashankar Telangana State Agricultural University, Rajendranagar, Hyderabad (Telangana), IN
2 Department of Genetics and Plant Breeding, College of Agriculture, Prof. Jayashankar Telangana State Agricultural University, Rajendranagar, Hyderabad (Telangana), IN
3 IRRI-South Asia Hub, ICRISAT campus, Patancheru, Hyderabad (Telangana), IN
4 Department of Crop Physiology, College of Agriculture, Prof. Jayashankar Telangana State Agricultural University, Rajendranagar, Hyderabad (Telangana), IN
Source
Asian Journal of Bio Science, Vol 11, No 1 (2016), Pagination: 151-161Abstract
Gene action and inheritance of quantitative traits associated with good out-pollination, agronomic and grain quality in restorer lines of rice was studied by generation mean analysis through six parameter model of Hayman. Eleven traits namely days to 50 per cent flowering, flag leaf area, plant height, number of panicles plant-1, panicle length, number of filled grains panicle-1, 100 seed weight, grain yield plant-1, kernel length, kernel breadth and kernel length/breadth ratio were studied in five crosses viz., BCW 56 / C20 R, BCW 56 / 1005, C 20 R / DR 714-1-2R, C 20 R / 1005 and DR 714-1-2R / 1005. The A, B, C and D scales are significant and epistasis was noticed for all the characters in all the crosses except for plant height in cross BCW56/C20R, 100 seed weight in C20 R/DR 714-1-2 Rand kernel breadth in C 20 R / 1005. Grain yield plant-1recorded dominance variance in all the crosses. Hence, heterosis breeding can be exploited in all the crosses by crossing the parents with high yielding CMS sources for identifying heterotic combinations. Additive and non additive gene effects with duplicate type of epistasis was observed for yield and quality characters like plant height, number of panicles plant-1, panicle length, number of filled grains panicle-1, 100 seed weight, grain yield plant-1, kernel length, kernel breadth and kernel L/B ratio in most of the crosses studied. Biparental mating, reciprocal recurrent selection and diallele selective mating systems could be exploited to obtain desirable recombinants having the characteristics of a restorer line with tallness, desirable flowering duration, reduced flag leaf area and more number of fertile spikelets. In crosses BCW 56 / C 20 R and BCW 56 / 1005 biparental mating followed by selection will be desirable to utilize both additive and non-additive gene action for number of filled grains panicle-1 and grain yield plant-1. The fixable gene effects namely additive (d) and additive x additive (i) gene effects were highly significant for the traits days to 50 per cent flowering in BCW 56 x C 20 R and C 20 R /DR 714-1-2Rand 100 seed weight in crosses BCW 56 /C 20 R and C 20 R/ 1005 and offer scope for improvement through phenotypic selection based on pedigree method in segregating generations by isolating desirable lines for the important floral, yield and quality traits for use as male parents in hybridization programmes.